The Network is constituted of representative members from commissioner and provider organisations in the region as well as other affiliated organisations including:
- Nottingham University Hospitals - Queens Medical Centre
- University Hospitals of Derby and Burton NHS Foundation Trust
- Chesterfield Royal Hospital
- University Hospitals of Leicester NHS Trust - Leicester Royal & Leicester General
- Sherwood Forest Hospitals NHS Foundation Trust - Kings Mill Hospital
- United Lincolnshire Hospitals NHS Trust - Lincoln and Boston Pilgrim Hospitals
- Kettering General Hospital
- Northampton General Hospital
- Independent Sector Hospitals (BMI, Spire Nottingham, Nuffield Derby, Ramsay Health Care, OneHealth, Three Shires)
- Commissioning Organisations for East Midlands region
- NHSE&I - Midlands and East Specialised Commissioners